- A retrospective analysis of subjects with gallbladder polyps (GPs) finds an incidence of gallbladder cancer (GBC) no different than subjects without GPs.
Why this matters
- The study suggests a need to revise guidelines that suggest following up GPs to prevent GBC, which were based on low levels of evidence.
- Retrospective observational cohort study drawn from Kaiser Permanente Northern California (n=622,227), including 35,856 with GPs (52% women; 43% Black/Hispanic/Asian; median age, 50 years).
- Funding: Kaiser Permanente Northern California.
- 71.1% had a quantitative size assessment, 68.8% had a GP
- 19 of 35,856 were diagnosed with GBC (11.3 [95% CI, 6.2-16.3] per 100,000 person-years).
- The rate of GBC increased with initial polyp size:
- 6 to
- ≥10 mm (128.2 [95% CI, 39.4-217.0] per 100,000 person-years).
- The unadjusted crude proportion of GBC with any GP was 0.053%, compared with 0.054% for adults with no GP (P=.94).
- After the first year, only 6 cases of GBC were diagnosed (3.6 [95% CI, 0.7-6.5] per 100,000 person-years).