- In patients with gastric cancer, high levels of tumor-infiltrating lymphocytes (TILs) in the tumor microenvironment are associated with positive prognosis.
Why this matters
- TILs may assist in selecting patients who may derive benefit from immune checkpoint inhibitor therapy.
- No scoring consensus exists for the evaluation of TIL in gastric cancer.
- Study to investigate a relationship between TIL levels and OS in 833 patients with gastric cancer.
- Funding: National Natural Science Foundation of China; Key R&D Project of Science and Technology Department of Jiangsu Province; Changzhou Health and Planning Commission Youth Talent Science and Technology Project.
- 78.17±2.00 months average survival with TILhi vs 41.21±2.09 months with TILlow (X2=148.762; P<.001>
- Superior prognosis with TILhi vs TILlow per Kaplan-Meier analysis (X2=174.77; P<.001>
- In multivariate Cox regression analysis, TILhi was an independent prognostic indicator for OS (HR, 0.431; 95% CI, 0.347-0.534; P<.0001>
- A nomogram was created incorporating TIL, histological grade, tumor size, nerve invasion, age, and pathological tumor and lymph node (pTN) stage; on validation, the nomogram demonstrated a greater concordance for predicting 3- and 5-year OS (C-index, 0.760; 95% CI, 0.704-0.815) vs pTN stage (C-index, 0.720) and TIL (C-index, 0.633).
- Retrospective data.