GDM carries a high risk for postpartum depression

  • Arafa A & al.
  • J Affect Disord
  • 2 May 2019

  • International Clinical Digest
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Takeaway

  • Gestational diabetes mellitus (GDM) significantly increases the risk of developing postpartum depression (PPD) symptoms.

Why this matters

  • Both GDM and PPD carry significant short- and long-term health consequences for women and their children.

Study design

  • Meta-analysis of 10 studies published between 2013 and 2018, with a total population of 2,000,002.
  • Funding: Japan Society for the Promotion of Science.

Key results

  • Pooled together, women with GDM compared with those without had a significantly increased risk of developing PPD symptoms:
    • Pooled relative risk (RR), 1.23 (95% CI, 1.08-1.39).
  • Heterogeneity was high across studies (I2=69.1%; Pheterogeneity=.001).
  • The association was highly modified by study design: 
    • Pooled RR for prospective studies: 1.95 (1.48-2.57) vs 
    • Pooled RR for retrospective cohort studies: 1.16 (1.12-1.21; Pinteraction=.003).
  • When analyzed separately, no evidence of heterogeneity seen in either retrospective (I2=0%; Pheterogeneity=.55) or prospective cohort studies (I2=22.1%; Pheterogeneity=.27).

Limitations

  • Assessment tools of PPD and GDM varied across studies, as did PPD scale cutoffs.
  • Some studies are based on self-reported data.
  • Several studies did not adjust for prenatal depression.

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