GERD: adjuvant lifestyle interventions improve outcomes

  • Yuan LZ & al.
  • Therap Adv Gastroenterol
  • 1 Jan 2019

  • International Clinical Digest
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Takeaway

  • Adjuvant lifestyle interventions improve outcomes over medication alone in gastroesophageal reflux disease (GERD).

Why this matters

  • Poor habits such as rapid eating, consumption beyond fullness, and intake of very hot foods can worsen GERD and reduce treatment efficacy.

Study design

  • Researchers surveyed patients with and without GERD from 6 hospitals (N=1518; 832 with GERD, 686 without GERD) to explore associations among symptoms, clinical characteristics, and lifestyle factors.
  • Funding: National Key Research and Development Program of China; National Natural Science Foundation of China; Central South University of China.

Key results

  • Logistic multivariate regression analysis showed these GERD risk factors:
    • Fast eating (OR, 4.06).
    • Eating beyond fullness (OR, 2.85).
    • Wearing girdles or corsets (OR, 2.19).
    • Eating very hot foods (OR, 1.81).
    • High BMI (OR, 1.81).
    • Lying down soon after eating (OR, 1.54).
    • Smoking (OR, 1.52).
  • Mann-Whitney rank sum testing showed lifestyle interventions in addition to medication improved 6-month outcomes over medication alone (U=35276.000; Z=−8.578; P<.001>

Limitations

  • Patient symptoms and lifestyle factors were self-reported.

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