A new study shows that gout has an independent association with the risk for progression of chronic kidney disease (CKD) in the UK health system. The findings were published in BMJ Open.
Researchers analysed the data for 68,897 patients with gout and 554,964 matched control patients from the UK Clinical Practice Research Datalink. The primary outcome was advanced CKD.
The incidence rate of advanced CKD was higher among patients with gout (8.54 [95% CI, 8.26-8.83] per 1000 patient-years) vs those without gout (4.08 [95% CI, 4.00-4.16] per 1000 patient-years). Gout was associated with a higher risk for advanced CKD in unadjusted analysis (HR, 2.00; 95% CI, 1.92-2.07) as well as adjusted analysis (HR, 1.29; 95% CI, 1.23-1.35). Among the components of advanced CKD, the association was strongest for end-stage kidney disease (HR, 2.13; 95% CI, 1.73-2.61).
According to the authors, the study "extends an emerging body of evidence that supports a role for chronic hyperuricaemia in the pathogenesis of CKD." They call for further research to determine whether adequate control of gout can lower the risk for CKD progression.