Gout tied to increased risk for advanced CKD

  • Stack AG & al.
  • BMJ Open
  • 28 Aug 2019

  • International Clinical Digest
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Takeaway

  • Gout is tied to a 29% increased risk for advanced chronic kidney disease (CKD), according to a large retrospective study from the UK health system.

Why this matters

Study design

  • Analysis of data for 68,897 primary-care patients with gout and 554,964 without gout captured in the UK Clinical Practice Research Datalink.
  • CKD was defined as composite of end-stage renal disease (ESRD), estimated glomerular filtration rate (eGFR, in mL/minute/1.73 m2)
  • Median follow-up was 3.68 years.
  • Funding: AstraZeneca.

Key results

  • Incidence of advanced CKD per 1000 patient-years was higher with gout (8.54; 95% CI, 8.26-8.83) than without (4.08; 95% CI, 4.00-4.16).
  • Gout was tied to an increased risk for advanced CKD in univariate analysis (HR=2.00; P<.001 somewhat attenuated in multivariate analysis findings were supported in: style="list-style-type:circle;">
  • Propensity score-matched analysis (aHR=1.23; 95% CI, 1.17-1.29).
  • Analysis limited to incident gout (aHR=1.28; 95% CI, 1.22-1.35).
  • Associations were observed with:
    • ESRD (aHR=2.13; P<.001>
    • eGFR
    • Serum creatinine doubling (aHR=1.13; P<.001>
  • Risk was observed across all gout groups with/without a history of CKD.
  • Limitations

    • Observational design.

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