- Gout is tied to a 29% increased risk for advanced chronic kidney disease (CKD), according to a large retrospective study from the UK health system.
Why this matters
- A recent US study tied gout to a 3-fold increased risk for overall CKD.
- The protective value of controlling gout remains unknown.
- Analysis of data for 68,897 primary-care patients with gout and 554,964 without gout captured in the UK Clinical Practice Research Datalink.
- CKD was defined as composite of end-stage renal disease (ESRD), estimated glomerular filtration rate (eGFR, in mL/minute/1.73 m2)
- Median follow-up was 3.68 years.
- Funding: AstraZeneca.
- Incidence of advanced CKD per 1000 patient-years was higher with gout (8.54; 95% CI, 8.26-8.83) than without (4.08; 95% CI, 4.00-4.16).
- Gout was tied to an increased risk for advanced CKD in univariate analysis (HR=2.00; P<.001 somewhat attenuated in multivariate analysis findings were supported in: style="list-style-type:circle;">
- Propensity score-matched analysis (aHR=1.23; 95% CI, 1.17-1.29).
- Analysis limited to incident gout (aHR=1.28; 95% CI, 1.22-1.35).
- ESRD (aHR=2.13; P<.001>
- Serum creatinine doubling (aHR=1.13; P<.001>
- Observational design.