Head/neck cancer: study identifies optimal time-to-treatment window

  • Oral Oncol

  • curated by Brian Richardson, PhD
  • Univadis Clinical Summaries
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Takeaway

  • Treatment time 42-60 days after diagnosis is associated with the best survival outcomes for patients with head and neck squamous cell carcinoma (HNSCC), according to a retrospective study.

Why this matters

  • The relationship between time to treatment and HNSCC outcomes is controversial.

Key results

  • Treatment time 42-60 days after diagnosis was associated with improved OS compared with treatment time >60 days after diagnosis (HR, 0.548; P<.01 in multivariate analysis.>
  • However, treatment time 28-41 days after diagnosis or 0-27 days after diagnosis were not significantly associated with improved OS compared with treatment time >60 days after diagnosis (HR, 0.790; P=.22 and HR, 0.756; P=.13, respectively).
  • In subgroup analysis, delayed treatment time was associated with worse OS in patient with T3/4 primary tumors (P=.02).

Study design

  • 633 patients with HNSCC treated with radiation alone or in combination with surgery and/or chemotherapy were included.
  • Funding: None.

Limitations

  • Retrospective study.