- Treatment time 42-60 days after diagnosis is associated with the best survival outcomes for patients with head and neck squamous cell carcinoma (HNSCC), according to a retrospective study.
Why this matters
- The relationship between time to treatment and HNSCC outcomes is controversial.
- Treatment time 42-60 days after diagnosis was associated with improved OS compared with treatment time >60 days after diagnosis (HR, 0.548; P<.01 in multivariate analysis.>
- However, treatment time 28-41 days after diagnosis or 0-27 days after diagnosis were not significantly associated with improved OS compared with treatment time >60 days after diagnosis (HR, 0.790; P=.22 and HR, 0.756; P=.13, respectively).
- In subgroup analysis, delayed treatment time was associated with worse OS in patient with T3/4 primary tumors (P=.02).
- 633 patients with HNSCC treated with radiation alone or in combination with surgery and/or chemotherapy were included.
- Funding: None.
- Retrospective study.