- Men with higher prediagnostic levels of circulating dehydroepiandrosterone (DHEA) and estradiol have a 34%-38% lower risk for esophageal adenocarcinoma (EA) and gastric cardia adenocarcinoma (GCA), the first evidence of an association of these sex hormones and reduced EA/GCA risk.
Why this matters
- Age-adjusted EA/GCA rates are 4-8 times higher in men than women.
- 259 patients with EA/GCA and 259 control participants, all male, pooled from the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial; Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study; and Cancer Prevention Study II Nutrition Cohort.
- Funding: National Institutes of Health.
- A doubling in circulating concentration of DHEA was associated with a 38% lower EA/GCA risk (OR per 1-unit increase in log2 DHEA, 0.62; 95% CI, 0.47-0.82).
- A doubling in circulating concentration of estradiol was associated with a 34% lower EA/GCA risk (OR per 1-unit increase in log2 estradiol, 0.66; 95% CI, 0.45-0.98).
- Associations remained significant after multivariable adjustment.
- Too few women to study the association between female sex hormones and cancer risk.