High-risk HPV tied to increased risk for incident CVD

  • Joo EJ & al.
  • Circ Res
  • 7 Feb 2019

  • curated by Liz Scherer
  • Clinical Essentials
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Takeaway

  • High-risk HPV infection is independently, significantly associated with increased cardiovascular disease (CVD) events risk, especially among obese women with metabolic syndrome (MetS).

Why this matters

  • Incorporate CVD prevention within management strategies in high-risk, young-to-middle-aged female HPV patients.
  • Routinely screen obese HPV patients with MetS to reduce overall CVD risk, promote timely interventions.

Key results

  • 63,411 participants, high-risk HPV prevalence was 7.6%.
  • Rate of new-onset CVD: 1122 cases, 4.3/1000 person-years.
  • Multivariate adjusted HR (aHR) for mediation by inflammation: 1.25 (95% CI, 1.03-1.52) for high-risk HPV-positive vs high-risk HPV-negative.
  • Multivariate aHR in high-risk, HPV-positive, nonobese (1.13; 95% CI, 0.90-1.43) vs obese (1.71; 95% CI, 1.17-2.50), P=.02.
  • Multivariate aHR for incident CVD in high-risk non-MetS (1.09; 95% CI, 0.87-1.36) vs MetS (1.99; 95% CI, 1.28-3.08), respectively, P=.05.

Study design

  • Prospective cohort study evaluating the longitudinal effect of high-risk HPV on the development of CVD events, influence of obesity among young and middle-aged Korean adult women.
  • Funding: National Research Foundation of Korea.

Limitations

  • Spontaneous HPV regression, incident cases not included.
  • HPV testing bias.
  • Specific HPV genotypes unexplored.
  • Nongeneralizable.