High serum uric acid may prevent fractures

Access to the full content of this site is available only to registered healthcare professionals. Register to read more

Higher levels of serum uric acid (UA) may lower the risk for fracture, according to a study published in the journal Osteoporosis International.

Researchers conducted a systemic review and meta-analysis of 5 prospective (n=29,110) studies identified after a search on PubMed, Embase, and Cochrane databases.

A random-effect model of all 5 studies showed a pooled HR of 0.79 (95% CI, 0.69-0.89) for higher UA and fractures. Pooled analysis of 3 high-quality studies showed a similar result (HR, 0.80; 95% CI, 0.69-0.93). In a sub-group analysis by types of fracture, population settings, and treatment with osteoporosis medications, the results remained similar to those in the primary analysis.