Higher levels of serum uric acid (UA) may lower the risk for fracture, according to a study published in the journal Osteoporosis International.
Researchers conducted a systemic review and meta-analysis of 5 prospective (n=29,110) studies identified after a search on PubMed, Embase, and Cochrane databases.
A random-effect model of all 5 studies showed a pooled HR of 0.79 (95% CI, 0.69-0.89) for higher UA and fractures. Pooled analysis of 3 high-quality studies showed a similar result (HR, 0.80; 95% CI, 0.69-0.93). In a sub-group analysis by types of fracture, population settings, and treatment with osteoporosis medications, the results remained similar to those in the primary analysis.