- Increased systolic BP is a risk for valvular heart disease, with a 20-mmHg increase tied to tripled odds in genetically associated BP.
Why this matters
- Pinning down modifiable risk factors for valvular heart disease has proved difficult, but targeting systolic BP reductions looks like a preventive avenue.
- In this Mendelian analysis, systolic BP was linked to valvular heart disease, with each 20-mmHg increase tied to aORs (95% CIs) of:
- Aortic stenosis: 3.26 (1.50-7.10);
- Aortic regurgitation: 2.59 (0.75-8.92);
- Mitral regurgitation: 2.19 (1.07-4.47); and
- For any valve disease: 2.85 (1.69-4.78).
- Risks based only on clinical data were similarly increased, but not as steeply.
- These findings held up on sensitivity analyses.
- Analysis of data from the UK Biobank, including 329,237 people ages 40-96 years.
- Single DNA changes were associated with systolic BP.
- Funding: UK foundations, government.
- Low representation for some types of valve disease, so wide CIs.
- Ethnically homogeneous population.