A recent meta-analysis published in the journal Frontiers in Neurology suggests that patients with epilepsy may have significantly higher levels of C-reactive protein (CRP) in the peripheral blood.
Researchers performed a meta-analysis of 16 case-control studies (n=1918) identified through a literature search on PubMed, EMBASE and the Cochrane Library databases.
A pooled analysis showed that patients with epilepsy had significantly higher peripheral blood levels of CRP than healthy individuals (standard mean difference [SMD], 0.43; 95% CI, 0.19-0.67). A sub-group analysis by age showed that the above association was true in adult patients (SMD, 0.47; 95% CI, 0.21-0.73) but not in children (SMD, 0.26; 95% CI, −0.48 to 0.99).
According to the authors, the study findings indicate "a potential association between inflammation and epilepsy." They call for further research to investigate the precise role of CRP in the pathophysiology of epilepsy.