Higher opioid dose results in worse patient-reported pain outcomes | APS

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  • Higher prescription opioid dose is associated with worse patient-reported pain outcomes and more health care utilization. 

Why this matters  

  • Previous research has examined pain-related variables on the basis of prescription opioid dose, but data from studies involving patient-reported outcomes have been limited. 

Study design  

  • Ohio State University investigators examined the relationships between prescription opioid dose and self-reported pain intensity, function, quality of life, and mental health.
  • Participants with musculoskeletal pain diagnoses who were receiving stable doses of long-term opioid therapy were recruited from two large integrated health systems.
  • The researchers assigned participants into one of three groups on the basis of current prescription opioid dose in daily morphine equivalents.
  • They were low dose (5-20 mg MED), moderate dose ...