Higher serum IGF-1 concentrations linked to lower risk of COVID-19 mortality

  • Fan X & al.
  • Eur J Epidemiol
  • 9 Jan 2021

  • curated by Sarfaroj Khan
  • UK Clinical Digest
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Takeaway

  • This study found an inverse association between pre-diagnostic serum insulin-like growth factor-1 (IGF-1) concentrations and COVID-19 mortality risk among patients with COVID-19.

Why this matters

  • Findings suggest a potential role of IGF-1 in COVID-19 prognosis and have implications for risk stratification and tailored treatment of patients with COVID-19.
  • Further studies are needed to determine whether and how targeting IGF-1 pathway might improve COVID-19 prognosis.

Study design

  • This observational study included 1670 patients with COVID-19 using data from the UK Biobank.
  • Association between IGF-1 concentrations and mortality risk among patients with COVID-19 who had pre-diagnostic serum IGF-1 measurements at baseline (2006-2010) was evaluated.
  • Funding: National Natural Science Foundation of China and others.

Key results

  • A total of 415 deaths occurred because of COVID-19.
  • Compared with the lower quartile (Q1) of IGF-1 concentrations, the highest quartile (Q4) was associated with a reduced risk of COVID-19 mortality (adjusted OR [aOR], 0.59; 95% CI, 0.41-0.86; Ptrend=.01).
  • In the continuous model, per 1-standard deviation increment in log-transformed IGF-1 was associated with a lower risk of COVID-19 mortality (intraclass correlation coefficients corrected aOR, 0.85; 95% CI, 0.73-0.99).
  • The association was largely consistent across various stratified and sensitivity analyses.
  • The association appeared to be stronger in non-White participants and non-smokers (both P-interaction <.05>

Limitations

  • Observational nature of the study prevented from inferring causality.
  • A single IGF-1 measurement at baseline may not represent the levels over 10 years.