HIV: is 95% adherence essential for viral suppression? Not for single-pill regimens

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Takeaway

  • Reaching the 95% or more adherence threshold is less important for patients with HIV receiving single-tablet regimens (STRs) than for multiple-tablet regimens (MTRs).

Why this matters                                                                             

  • Poor adherence is associated with antiretroviral therapy (ART) resistance, progression to AIDS, and transmission of the virus.

Key results

  • Viral suppression was statistically similar between STR participants with 80%-94% adherence.
  • STR participants were 2.57-fold more likely to be virally suppressed with 95% adherences vs <80% adherence.
  • OR was 6.89 for MTR participants with 95% adherence vs 85%-89% adherence.
  • MTR...