- Reaching the 95% or more adherence threshold is less important for patients with HIV receiving single-tablet regimens (STRs) than for multiple-tablet regimens (MTRs).
Why this matters
- Poor adherence is associated with antiretroviral therapy (ART) resistance, progression to AIDS, and transmission of the virus.
- Viral suppression was statistically similar between STR participants with 80%-94% adherence.
- STR participants were 2.57-fold more likely to be virally suppressed with >95% adherences vs <80% adherence.
- OR was 6.89 for MTR participants with >95% adherence vs 85%-89% adherence.
- MTR participants were 7.61-fold as likely to be virally suppressed at >95% adherence vs 80%-84% adherence.
- MTR participants were more than 10-fold as likely to be virally suppressed if they were >95% adherent vs <80% adherent.
- Retrospective cohort study.
- 1536 patients receiving STR or MTR ART were included.
- Funding: None.
- Only 477 participants received STR ART, limiting the power of these findings.
- Adherence was measured by prescriptions filled.
- Primary patient population was middle-aged and African American.