In acne patients, isotretinoin associated with lower depression
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A systematic review eases concerns that isotretinoin may lead to increased depression, and instead shows a decrease.
Why this matters
No quantitative analysis of isotretinoin and depression had previously been conducted.
The researchers conducted a meta-analysis of 31 studies.
After isotretinoin treatment depression prevalence declined (risk ratio, 0.588), and there was a statistically significant decline in depression scores after treatment (standardized mean difference, −0.335).