- A systematic review eases concerns that isotretinoin may lead to increased depression, and instead shows a decrease.
Why this matters
- No quantitative analysis of isotretinoin and depression had previously been conducted.
- The researchers conducted a meta-analysis of 31 studies.
- Funding: None.
- After isotretinoin treatment depression prevalence declined (risk ratio, 0.588), and there was a statistically significant decline in depression scores after treatment (standardized mean difference, −0.335).
- An analysis of 6 controlled studies showed improvements in baseline depression scores for patients treated with isotretinoin or an alternative therapy, with no significant difference between the 2 groups.
- None of the included studies were randomized controlled trials.
- There was large inter-study variability.