- After chemotherapy and surgery, there was no difference in survival among patients with clinically lymph node-positive (cLNP) and pathologically proved lymph node-positive (pLNP) intrahepatic cholangiocarcinoma.
Why this matters
- The presence of lymph node metastasis should not be a contraindication for resection.
- Retrospective analysis of records from the National Cancer Database (n=1023).
- Funding: NIH.
- 23% of patients underwent resection. 15% underwent resection with chemotherapy. 67% of chemotherapy was in the adjuvant setting, 33% neoadjuvant. There was no difference in OS based on chemotherapy sequence.
- Median survival was 13.6 months.
- There was no difference in survival between resection alone (12.5 months) and chemotherapy alone (11.9 months; P=.226).
- Combination resection and chemotherapy was associated with longer survival (median, 22.5 months; P<.001>
- A multivariate analysis showed combination of resection and chemotherapy improved survival (HR, 0.53; P<.001>
- There was no survival difference among patients receiving chemotherapy and resection based on cLNP (22.5 months) vs pLNP status (19.3 months; P=.995).
- Retrospective analysis.