- Prenatal cannabis exposure after the early weeks of gestation increases risk slightly for psychosis proneness in middle childhood.
- The authors call the associations “robust.”
Why this matters
- As cannabis use becomes more common, these authors warn that their findings reinforce recommendations that pregnant women avoid using cannabis “until more is known."
- 4.61% of children were exposed to cannabis in utero:
- 138 only before maternal knowledge of pregnancy.
- 61 before and after maternal knowledge of pregnancy.
- 2 only after maternal knowledge of pregnancy.
- With exclusion of fixed-effect covariates, maternal cannabis use after knowledge of pregnancy was associated with proneness to psychosis in the child (P=.004).
- Data from the Adolescent Brain Cognitive Development study .
- Psychosis proneness tested using the Prodromal Questionnaire-Brief Child Version.
- 4361 children (with 3774 mothers) tested from ages 8.9 to 11.0 years (born 2005-2008).
- Funding: NIH.
- Small numbers exposed prenatally to cannabis.
- Possible underreporting of cannabis use.
- Conversion rate of psychosis proneness to psychosis not clear.