Inactivated quadrivalent influenza vaccine: time to double the dose in young children?
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In children aged 6-17 mo, double-dose inactivated quadrivalent influenza vaccine (IIV4) demonstrated immunogenic noninferiority compared to standard-dose for all strains, with selective superior immunogenicity for B strains in a post hoc analysis.
Why this matters
Primary requirement for US licensure criteria was demonstrated, supporting a potential future change in clinical practice toward double-dose IIV4 in all children aged 6 mo and older.