- Stroke occurrence within 1 year was common in patients with acute coronary syndrome (ACS) who underwent percutaneous coronary intervention (PCI).
- Post-PCI stroke occurrence had a significantly greater effect on subsequent 30-day mortality compared with myocardial infarction (MI) and bleeding, but the association was no longer significant after 30 days of stroke occurrence.
Why this matters
- The findings highlight that the implementation of measures to prevent the occurrence of stroke in patients with ACS who underwent PCI may improve prognosis.
- 19,914 patients with ACS who underwent PCI were included using the data from the PROMETHEUS study.
- Primary outcome: cumulative stroke incidence and all-cause mortality at 30 days and 1 year.
- Other outcomes: risk for MI and bleeding.
- Funding: Daiichi Sankyo and Eli Lilly and Company.
- Of 19,914 patients with ACS, 244 reported strokes within 1-year follow-up with a cumulative incidence of 1.5% (95% CI, 1.3-1.6%).
- Previous cardiovascular disease was the independent predictor of stroke (HR, 5.37; P<.0001 followed by st-elevation mi p non-st-elevation hypertension smoking female sex and age>
- The risk for all-cause mortality was significantly higher in patients with stroke vs those without (adjusted HR [aHR], 4.84; P<.0001>
- Patients with stroke were at increased risk for mortality in the subsequent 30 days (aHR, 17.7; P<.0001 vs beyond days p=".58).</li">
- Retrospective design.
- Risk of unmeasured confounding.