- Adding hypertensive disorders of pregnancy (HDPs) history and parity to cardiovascular disease (CVD) risk prediction in a low-risk population does not improve risk stratification.
Why this matters
- As independent factors, HDPs and parity showed associations with 10-year CVD risk:
- No HDP, 1 birth: HR, 1.42 (95% CI, 1.12-1.80) vs no HDP and 2 births.
- HDP, 2 births: HR, 2.02 (95% CI, 1.50-2.72) vs no HDP and 2 births.
- Adding them to the model did not affect risk reclassification or improve discrimination overall.
- However, greater CVD risk for history of no HDP/1 birth or HDP/2 births persisted for women aged 40-49 years.
- n=67,406 women, Nurses’ Health Study II.
- Age ≥40 years, no CVD history.
- Followed for fatal coronary heart disease, myocardial infarction, stroke, 1989-2013.
- 2 models were used:
- Total cholesterol, high-density lipoprotein cholesterol, systolic BP, antihypertensives use, current smoking, diabetes, or
- All of the above plus HDP and parity.
- Predicted probabilities for 10-year CVD risk vs CVD outcomes.
- Funding: NIH.
- Self-reported BP values, cholesterol levels not directly measured.