- Patients with inflammatory bowel disease (IBD) show an increased long-term risk for type 2 diabetes (T2D) that is greatest during the first year after IBD diagnosis.
Why this matters
- Patients with Crohn’s disease (CD) or ulcerative colitis (UC) may benefit from T2D screening.
- Researchers analysed health data for a population-based cohort in Denmark (n=6,028,844; follow-up, 736,072 person-years), comparing the T2D status of patients with IBD to those without IBD and calculating standardised incidence ratios (SIRs) to assess T2D risk.
- Funding: Novo Nordisk Foundation.
- 3436 patients with IBD developed T2D vs 2224 expected cases: SIR, 1.54 (95% CI, 1.49-1.60).
- T2D risk was highest during the first year after a diagnosis of IBD: SIR, 4.48 (95% CI, 4.16-4.83).
- Risk persisted for 20 or more years after the diagnosis: SIR, 1.26 (95% CI, 1.16-1.38).
- Patient data did not include potential confounders, such as BMI or smoking status.