- Women with Roux-en-Y gastric bypass surgery had fewer infants with birth defects.
Why this matters
- Obesity is related to poor glucose control, which is teratogenic.
- There were fewer birth defects in women with Roux-en-Y gastric bypass surgery compared with matched controls (3.4% vs 4.9%; risk ratio, 0.67; 95% CI, 0.52-0.87).
- Mean weight loss in the surgery group was 40 kg; diabetes drug use decreased from 9.7% before surgery to 1.5% during the 6 months prior to conception.
- Retrospective matched cohort study comparing women and infants with and without Roux-en-Y gastric bypass surgery.
- Cohort obtained from a Swedish Medical Birth Register and from the Scandinavian Obesity Surgery Register from the same period.
- Controls were matched by maternal presurgery BMI, diabetes, history of birth defects, delivery year, and a propensity score based on maternal age, alcohol and substance abuse, smoking, parity, and number of prescription drugs.
- Funding: National Institute of Diabetes and Digestive and Kidney Diseases, NIH, the Swedish Research Council, and the Swedish Research Council for Health, Working Life, and Welfare.
- Pregnancy terminations and stillbirths were not included.