- This meta-analysis suggests a positive association between Helicobacter pylori (H pylori) infection and diabetes mellitus.
Why this matters
- Several studies have investigated the role of H pylori in the pathogenesis of diabetes and its complications, but the results are inconsistent with each other.
- Meta-analysis of 41 case-control studies included 9559 participants (4327 cases and 5232 controls) after a search across electronic databases.
- Funding: None.
- A significant positive association was observed between H pylori infection and diabetes (pooled OR, 1.27; 95% CI, 1.11-1.45; I2=86.6%).
- In the subgroup analysis, H pylori infection was associated with an increased risk for diabetes mellitus (both types) (OR, 1.17; 95% CI, 0.94-1.45; I2=82.5%), type 1 (OR, 1.19; 95% CI, 0.98-1.45; I2=81.6%) and type 2 (OR, 1.43; 95% CI, 1.11-1.85; I2=90.0%) diabetes.
- In the subgroup analysis by the geographical regions, the Asian population with H pylori infection were at slightly higher risk for diabetes compared with other population.
- Heterogeneity among studies.
- Only case-control studies were included.