Is H pylori infection a risk factor for diabetes mellitus?

  • Mansori K & al.
  • BMC Gastroenterol
  • 24 Mar 2020

  • curated by Sarfaroj Khan
  • UK Clinical Digest
Access to the full content of this site is available only to registered healthcare professionals. Access to the full content of this site is available only to registered healthcare professionals.

Takeaway

  • This meta-analysis suggests a positive association between Helicobacter pylori (H pylori) infection and diabetes mellitus.

Why this matters

  • Several studies have investigated the role of H pylori in the pathogenesis of diabetes and its complications, but the results are inconsistent with each other.

Study design

  • Meta-analysis of 41 case-control studies included 9559 participants (4327 cases and 5232 controls) after a search across electronic databases.
  • Funding: None.

Key results

  • A significant positive association was observed between H pylori infection and diabetes (pooled OR, 1.27; 95% CI, 1.11-1.45; I2=86.6%).
  • In the subgroup analysis, H pylori infection was associated with an increased risk for diabetes mellitus (both types) (OR, 1.17; 95% CI, 0.94-1.45; I2=82.5%), type 1 (OR, 1.19; 95% CI, 0.98-1.45; I2=81.6%) and type 2 (OR, 1.43; 95% CI, 1.11-1.85; I2=90.0%) diabetes.
  • In the subgroup analysis by the geographical regions, the Asian population with H pylori infection were at slightly higher risk for diabetes compared with other population.

Limitations

  • Heterogeneity among studies.
  • Only case-control studies were included.