Is HPV associated with female infertility?

  • Yuan S & al.
  • Reprod Biomed Online
  • 16 Nov 2019

  • curated by Elisabeth Aron, MD, MPH, FACOG
  • Clinical Essentials
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Takeaway

  • High-risk (HR) HPV may be associated with an increased risk for female infertility.

Why this matters

  • Infertility affects 8%-12% reproductive-aged couples worldwide.
  • The prevalence of secondary infertility varies with geographic location; the highest rates are in South Asia, Africa, the Middle East, Central and Eastern Europe, and Central Asia.
  • People with HR-HPV may also have other sexually transmitted infections that contribute to secondary infertility.
  • People with infertility should be screened for HPV.
  • Immunization against HPV should be implemented.

Key results

  • No association between all types of HPV and female infertility (7 studies; P=.06).
  • HR-HPV associated with increased risk for female infertility (6 studies; OR, 2.33; P=.0008); however, HPV was not an independent risk factor.

Study design

  • Systematic search and meta-analysis (11 studies included in meta-analysis).
  • Funding: Chengdu Science and Technology Huimin Technology Research and Development Project.

Limitations

  • Limitations based on the limitations of original studies.
  • Heterogeneity between studies.