- Lower glomerular filtration rate (GFR) level was independently associated with a higher burden of Afib in adults with Afib measured by 14-day continuous ambulatory ECG monitoring.
- Reduced kidney function may increase the risk of stroke through inducing a higher incidence of Afib and Afib burden.
Why this matters
- Afib is the main risk factor for ischemic stroke; a high Afib burden (i.e., time spent with Afib) independently increases the risk of stroke.
- Reduced kidney function is associated with higher risk of Afib, yet it is unknown how it influences the Afib burden.
- KP RHYTHM included adults who had 14-day continuous ambulatory ECG monitoring between 2011 and 2016.
- Study patients had GFR estimated by CKD-EPI the year before monitoring, were not receiving renal replacement therapy, and had Afib detected in the monitoring period.
- Patient-specific characteristics and stroke risk factors were obtained from electronic health records.
- Researchers analyzed the multivariable association of a 10 mL/minute/1.73 m2 decrease in estimated GFR (eGFR) with Afib burden.
- A total of 1069 adults with detected Afib on ambulatory monitoring were enrolled.
- Median Afib burden was 4% (interquartile range, 1%-13%).
- After adjustment for comorbidities (heart failure, hypertension, diabetes mellitus, prior stroke, proteinuria) and demographics, every 10 mL/minute/1.73 m2 lower level of eGFR was independently associated with 10% higher burden of Afib (95% CI, 1.1%-19%).
- Short-term monitoring period of 14 days.