knee osteoarthritis: Strenuous exercise and extensive sitting


  • Heather Mason
  • Univadis Medical News
Access to the full content of this site is available only to registered healthcare professionals. Access to the full content of this site is available only to registered healthcare professionals.

No association exists between long-term strenuous physical activity and incident radiographic knee osteoarthritis (KOA), according to a study reported in JAMA Network Open.

This secondary analysis from a prospective cohort from the Osteoarthritis Initiative (OAI) studied 1,194 patients at high risk of, but without radiographic evidence for, KOA.

Inclusion criteria were Kellgren and Lawrence grade of 0 in both knees and completion of a PASE (Physical Activity Scale for the Elderly) questionnaire, which enquired about frequency and duration of exercise over the previous seven days, estimated over an eight-year period.

Patients were classified into the persistently no exercise subgroup (0 h/wk)(49.7%), the low (29.6%), or slightly improving subgroup (1-2 h/wk).

More than 40 per cent were classified into moderate (32.3%) to high (10.1%) frequency of extensive sitting subgroup, who were older, had higher BMI, and more severe knee pain. Being a college graduate and having stronger quadriceps were each associated with an increased likelihood of membership in the high, improving exercise subgroup.

Long-term engagement in low-to-moderate physical activities (adjusted odds ratio [OR] 0.69; 95% CI 0.48-1.01) or any strenuous physical activities (adjusted OR 0.75; 95% CI 0.53-1.07) was not associated with 10-year incident radiographic KOA.