- Lighter drinking appeared to protect against dementia among older adults who did not have mild cognitive impairment (MCI), while heavier drinking appeared detrimental among older adults who had MCI.
Why this matters
- Large and increasing burden of dementia.
- Dementia incidence during median 6.0-year follow-up: 16.9%.
- Compared with
- Without MCI: HR, 0.63 (95% CI, 0.38-1.06).
- With MCI: HR, 0.93 (95% CI, 0.47-1.84).
- Complete abstention among those without MCI.
- Intake >14.0 drinks/week among those with MCI.
- Retrospective cohort study: 3021 community-dwelling adults aged ≥72 years free of dementia (15.7% had MCI).
- Main outcome: dementia.
- Funding: National Center for Complementary and Alternative Medicine; National Institute of Neurological Disorders and Stroke; others.
- Alcohol intake was self-reported.
- Unknown generalisability to younger age-groups.
- Possibility of inverse association.