- Low initial maternal serum levels of human chorionic gonadotrophin (HCG) are associated with low rates of clinical pregnancy and live birth, as well as high rates of miscarriage after vitrified-warmed single-blastocyst transfer.
Why this matters
- This study adds evidence for a predictive role of HCG in pregnancy outcomes and identifies cutoff values.
- At a cutoff value of 152.2 IU/L, HCG levels had an area under the curve (AUC) of 0.95 for clinical pregnancy prediction.
- At a cutoff value of 211.9 IU/L, HCG levels had an AUC of 0.81 for ongoing pregnancy and 0.79 for live birth prediction.
- 640 women who received vitrified-warmed single-blastocyst transfer were analyzed for HCG levels on day 11 and associations with outcomes.
- Funding: Basic Research Program of Shenzhen; National Natural Science Foundation of China.
- Retrospective study.