Low maternal HCG predicts poor pregnancy outcomes after blastocyst transfer

  • Xiong F & al.
  • Reprod Biomed Online
  • 5 Jan 2019

  • curated by Brian Richardson, PhD
  • Clinical Essentials
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Takeaway

  • Low initial maternal serum levels of human chorionic gonadotrophin (HCG) are associated with low rates of clinical pregnancy and live birth, as well as high rates of miscarriage after vitrified-warmed single-blastocyst transfer.

Why this matters

  • This study adds evidence for a predictive role of HCG in pregnancy outcomes and identifies cutoff values.

Key results

  • At a cutoff value of 152.2 IU/L, HCG levels had an area under the curve (AUC) of 0.95 for clinical pregnancy prediction.
  • At a cutoff value of 211.9 IU/L, HCG levels had an AUC of 0.81 for ongoing pregnancy and 0.79 for live birth prediction.
  • HCG

Study design

  • 640 women who received vitrified-warmed single-blastocyst transfer were analyzed for HCG levels on day 11 and associations with outcomes.
  • Funding: Basic Research Program of Shenzhen; National Natural Science Foundation of China.

Limitations

  • Retrospective study.

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