- Men with low testosterone have 41% lower odds of kidney stones (KS) than other men, after multivariable adjustment (OR, 0.59).
Why this matters
- "[T]estosterone could have a biologic role in KS formation," say researchers.
- Results persisted when researchers stratified men with low testosterone by obesity (−59% lower odds) and high-density lipoprotein ≥ 40 mg/dL (−40% lower odds).
- Men without diabetes and low testosterone had 39% lower odds of KS, but researchers found no significant association in diabetic men with low testosterone and other comorbidities.
- With stratification by age, men 40-59 years old with low testosterone had 68% lower odds of KS (OR, 0.32).
- White men with low testosterone had 48% lower odds of KS (OR, 0.52); Hispanic men with low testosterone had 2.36 times higher odds of KS (OR, 2.36).
- Researchers analyzed data from the National Health and Nutrition Examination Survey to determine the association between low testosterone (≤3 ng/mL) and prevalence of KS (n=8626; age, ≥20 years; 100% men).
- Funding: None.
- The study was cross-sectional and did not demonstrate causality.