Low testosterone tied to fewer kidney stones

  • Yucel E & al.
  • Prev Med Rep
  • 1 Jun 2018

  • curated by Craig Hicks
  • Clinical Essentials
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Takeaway

  • Men with low testosterone have 41% lower odds of kidney stones (KS) than other men, after multivariable adjustment (OR, 0.59).

Why this matters

  • "[T]estosterone could have a biologic role in KS formation," say researchers.

Key results

  • Results persisted when researchers stratified men with low testosterone by obesity (−59% lower odds) and high-density lipoprotein ≥ 40 mg/dL (−40% lower odds).
  • Men without diabetes and low testosterone had 39% lower odds of KS, but researchers found no significant association in diabetic men with low testosterone and other comorbidities.
  • With stratification by age, men 40-59 years old with low testosterone had 68% lower odds of KS (OR, 0.32).
  • White men with low testosterone had 48% lower odds of KS (OR, 0.52); Hispanic men with low testosterone had 2.36 times higher odds of KS (OR, 2.36).

Study design

  • Researchers analyzed data from the National Health and Nutrition Examination Survey to determine the association between low testosterone (≤3 ng/mL) and prevalence of KS (n=8626; age, ≥20 years; 100% men).
  • Funding: None.

Limitations

  • The study was cross-sectional and did not demonstrate causality.

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