LRC: high BMI tied to complications after radical resection

  • Zhang X & al.
  • Surg Today
  • 18 Feb 2019

  • curated by David Reilly
  • Univadis Clinical Summaries
Access to the full content of this site is available only to registered healthcare professionals. Access to the full content of this site is available only to registered healthcare professionals.

Takeaway

  • In patients undergoing radical resection for low-lying rectal cancer (LRC), higher BMI is associated with longer operative time, longer postoperative hospital stay, and increased incidence of postoperative complications.
  • Higher BMI in this setting was not linked to survival outcomes.

Why this matters

  • Radical resection is an optimal choice in patients with LRC.

Study design

  • Study to investigate the effect of increased BMI in surgical outcomes in 792 patients who underwent LRC resection.
  • Patients were stratified into 3 groups:
    • Controls: BMI 2 (n=624).
    • Overweight: BMI 25-30 kg/m2 (n=147).
    • Obese: BMI ≥30 kg/m2 (n=21).
  • Data source: colorectal cancer database of the Department of Gastrointestinal Surgery, West China Hospital, Sichuan University.
  • Funding: Science and Technology Support Program, Science and Technology Department of Sichuan Province.

Key results

  • High BMI was associated with significantly longer:
    • Operative time: P<.001.>
    • Postoperative hospital stay: P=.032.
  • Patients with increased BMI had significantly increased incidence of:
    • Pulmonary infection: P=.008.
    • Anastomotic leakage: P=.029.
    • Allergy: P=.017.
    • Long-term complication: P=.034.
    • Incisional hernia: P=.015.
  • No significant difference between groups in terms of OS (P=.734) or disease-free survival (P=.801).

Limitations

  • Retrospective data.

Please confirm your acceptance

To gain full access to GPnotebook please confirm:

By submitting here you confirm that you have accepted Terms of Use and Privacy Policy of GPnotebook.

Submit