Many patients with epilepsy meet criteria for major depressive disorder | AES


  • Conference reports - RSi Communications
Access to the full content of this site is available only to registered healthcare professionals. Access to the full content of this site is available only to registered healthcare professionals.

Takeaway

  • As many as 3 out of 10 patients with epilepsy meet formal criteria for major depressive disorder.

Why this matters

  • Little is known about rates of depression in older adults with epilepsy.

Study design

  • Researchers at Rush University in Chicago retrieved the electronic medical record of all patients seen at the Rush Epilepsy Clinic in 2014-2016.
  • Patients ≥60 years with a confirmed diagnosis of epilepsy were included.

Key results

  • 73 patients (48 female) have been identified; the mean age was 66.
  • The average duration of epilepsy was 17 years; median seizure frequency was 1 year.
  • The majority were on a single antiepileptic drug (AED), 9 required three AEDs, and 14 required 2.
  • The average score on the NDDI-E was 11+/- 4 (>10 is diagnostic for depression) and on the PHQ-GAD-7 was 5 +/- 5 (>15 is diagnostic for anxiety).
  • 52% (n=38) scored positive for depression, while only 5% (n=4) scored positive for anxiety.
  • Approximately 17%-30% of patients will meet formal criteria for major depressive disorder and 21% of patients with poorly controlled temporal lobe epilepsy will have major anxiety disorder.