- Marine oil supplements alleviate the pain of rheumatoid arthritis but not osteoarthritis, according to a meta-analysis.
Why this matters
- 22.7% of US adults report medically diagnosed arthritis.
- 42 randomized controlled trials met eligibility criteria after a search on PubMed, the Cochrane Library, EMBASE, Web of Science, clinicaltrials.gov, and WHO International Clinical Trial Registry Platform portal.
- Cochrane Risk of Bias tool was used to evaluate risk for bias.
- The Grading of Recommendations Assessment, Development, and Evaluation criteria were used to evaluate the quality of the evidence.
- Funding: No external funding was used.
- The standardized mean difference (SMD) across eligible trials was favorable (SMD=−0.24).
- The SMD was significant for rheumatoid arthritis (22 trials; n=956; SMD=−0.21) and other or mixed rheumatoid/osteoarthritis (3 trials; n=150; SMD=−0.63).
- The SMD was not significant for osteoarthritis (5 trials; n=403; SMD=−0.17).
- The rheumatoid arthritis studies were of moderate quality, but the studies of other/mixed arthritis and osteoarthritis were of low quality.
- High heterogeneity across primary studies.