- A meta-analysis finds that anxiety has a prevalence of 21% in people with mild cognitive impairment (MCI), although there is high heterogeneity across studies.
Why this matters
- Anxiety is important to treat because it may confer a higher probability of progression to dementia.
- Systematic review and meta-analysis included 39 studies (n=10,587) on anxiety in patients with mild cognitive impairment.
- Funding: Hunan Provincial Innovation Foundation for Postgraduate.
- Anxiety had a pooled prevalence of 21% (95% CI, 16.2-26.7) in patients with mild cognitive impairment.
- The heterogeneity was significant (I2, 97.2%; P<.01>
- After stratification of the sample, the prevalence of anxiety was:
- Significantly lower in 21 community-based samples vs clinic-based samples from 18 studies (14.3% vs 31.2%; P<.01>
- 21.8%, 46.6%, and 16.9% for informant-rated, self-reported, and clinician-administered sources of anxiety diagnosis, respectively.
- Individual anxiety disorders were not reported.
- Inadequate data for stratified prevalence estimates.
- Prevalence of anxiety may be underestimated.
Coauthored with Chitra Ravi, MPharm