Meta-analysis: atopic dermatitis linked to depression, anxiety, and suicidal ideation

  • Rønnstad ATM & al.
  • J Am Acad Dermatol
  • 1 Sep 2018

  • curated by Brian Richardson, PhD
  • Clinical Essentials
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Takeaway

  • A systematic review and meta-analysis suggests that atopic dermatitis (AD) is associated with depression, anxiety, and suicidal ideation.

Why this matters

  • Meta-analysis supports prior evidence of link between AD and psychiatric problems and suggests that patients should be screened for symptoms.

Key results

  • AD in adults was associated with depression (OR, 2.19; 95% CI, 1.87-2.57) and anxiety (OR, 2.19; 95% CI, 1.75-2.73).
  • AD in children was associated with depression (OR, 1.27; 95% CI, 1.12-1.45).
  • AD in adults and adolescents was associated with suicidal ideation (OR, 4.32; 95% CI, 1.93-9.66).

Study design

  • 60 studies were subjected to meta-analysis to determine associations between AD and anxiety, depression, suicidal ideation, and completed suicide.
  • Funding: Lundbeck Foundation; Herlev and Gentofte Hospital.

Limitations

  • Various definitions of depression and anxiety used in studies.
  • Few studies analyzed AD severity.

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