- A meta-analysis finds that bacterial infections are implicated in 49.59% of acute COPD exacerbations.
Why this matters
- This is the first meta-analysis to identify the prevalence of bacterial infections in acute exacerbations.
- Meta-analysis of 118 studies (n=19,409 patients) after search of PubMed, ISI Web of Science, and Scopus.
- Funding: None disclosed.
- Bacterial infections have a prevalence of 49.59% (95% CI, 44.18%-55%) in acute COPD exacerbations, with high heterogeneity, I2=98.23%.
- The most prevalent bacteria were Streptococcus pneumoniae, Klebsiella pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, Acinetobacter baumannii, Pseudomonas aeruginosa, and Staphylococcus aureus.
- High heterogeneity.
- No examination of viral infections.