- Collagenase Clostridium histolyticum (CCH) and interferon α-2b are the best intralesional therapies for correcting penile curvature (PC) caused by Peyronie’s disease (PD).
- Hyaluronic acid has the greatest effect in restoring erectile function (EF).
Why this matters
- “Urologists should discuss medical therapy with patients before surgical correction, as well as the target of improvement that they expect to obtain,” say researchers.
- Researchers analyzed randomized controlled trials comparing ≥1 intralesional therapy with placebo or another drug for treating PD (8 trials; n=1050).
- Outcome measures were mean changes in PC in degrees and EF as assessed with the International Index of Erectile Function (IIEF) questionnaire.
- Funding: None.
- Mean PC treatment efficacy vs placebo (95% CIs):
- CCH: −0.41 (−19.0 to 18.17);
- interferon α-2b: −0.50 (−18.47 to 17.47);
- verapamil: 1.88 (−14.56 to 18.32); and
- hyaluronic acid: 6.25 (−13.56 to 6.06).
- Mean EF treatment efficacy vs placebo (95% CIs):
- hyaluronic acid: 1.78 (1.31-2.43);
- verapamil: 1.16 (0.16-2.16);
- CCH: −0.61 (−1.01 to −0.20); and
- interferon α-2b: 0.04 (−0.39 to 0.48).
- The analysis did not include other PD outcomes (pain, plaque size, and patient satisfaction) because of a lack of homogeneity across trials.