- Surgery offered better OS, cancer-specific survival (CSS), disease-free survival (DFS), and freedom from locoregional recurrence compared with stereotactic body radiation therapy (SBRT) for early-stage NSCLC, according to a new meta-analysis.
Why this matters
- Positive study results for SBRT in inoperable NSCLC have heightened interest in the benefit of SBRT in operable patients as well.
- The difference in outcomes may be due "at least in part to an imbalance of baseline characteristics," the authors note.
- Meta-analysis of 23 studies.
- Funding: NIH.
- Surgery offered better outcomes than SBRT in matched and unmatched cohorts for OS, CSS, DFS, and freedom from recurrence:
- OS: unmatched OR, 2.49 (P<.00001 matched or>
- CSS: unmatched OR, 2.44 (P<.00001 matched or>
- DFS: unmatched OR, 2.13 (P<.00001 matched or>
- Freedom from locoregional recurrence: unmatched OR, 5.44 (P <.005 matched or>
- Lack of randomized control trials.
- Patient selection bias.