- Fluorodeoxyglucose (FDG) uptake on positron emission tomography/CT (PET/CT) is negatively associated with response rate and disease control rate in patients with metastatic differentiated thyroid cancer (DTC) treated with radioactive iodine (RAI).
Why this matters
- Predicting response to RAI can help plan long-term treatment strategies.
- FDG uptake was negatively correlated with response rate (OR, 0.233; P=.016).
- In analysis according to the concordance rate of both tracers, RAI uptake was correlated with response rate (OR, 5.833; P=.01), while FDG uptake was inversely associated with disease control rate (OR, 0.241; P=.034).
- In lesion-based subgroup analysis, RAI uptake was correlated with disease control rate (OR, 5.2; P=.001), while FDG uptake was inversely correlated with disease control rate (OR, 0.095; P=.002).
- 54 patients with metastatic DTC treated with RAI therapy received FDG PET/CT and were analyzed for response and disease control rates.
- Funding: Drug Development Research, funded by the Ministry of Health & Welfare, Republic of Korea.
- Retrospective study.
- Small patient sample size.