Cetuximab and modified FOLFIRI (mFOLFIRI) appeared well tolerated and active as second-line treatment for patients with metastatic gastric cancer (MGC); low baseline plasma vascular endothelial growth factor (VEGF) levels were associated with better clinical outcomes.
Why this matters
MGC has a poor prognosis, with short median OS time.
Among 54 evaluable patients, response rate (RR) was 33.3%.
In the intention-to-treat population, median time to progression (TTP) was 4.6 mo; median OS was 8.6 mo.
Patients with low (≤12.6 pg/mL) vs high (12.6 pg/mL) baseline plasma VEGF levels had RR of 55.0% and 5.3%, respectively (P=.001).
Median TTP values were also improved (6.9 vs 2.8 mo, respectively; P=.0005), as was median OS (12 vs 5 mo; P<.0001).