- Intensity modulated radiotherapy (IMRT) with a median dose of 63.6 Gy was associated with similar locoregional failure-free survival (LRFS), distant metastasis-free survival (DMFS), disease-free survival (DFS), and OS as the standard dose of 70 Gy in patients with T1-3 nasopharyngeal carcinoma (NPC).
Why this matters
- Lower radiation doses are associated with reduced toxicity.
- In the entire cohort, 5-year LRFS was 93.6%, 5-year DMFS was 85.5%, 5-year DFS was 77.9%, and 5-year OS was 81.8%.
- In propensity score-matched analysis, patients who received a radiation dose
- LRFS (92.5% vs 91.7%; P=.863).
- DMFS (89.5% vs 88.1%; P=.947).
- DFS (75.9% vs 82.1%; P=.469).
- OS (82.1% vs 85.7%; P=.869).
- 266 patients with T1-3 NPC treated with IMRT were included.
- Propensity score matching identified 32 patients treated with a de-escalated dose (
- Funding: National Natural Science Foundation of China.
- Retrospective design.