- Sleeve gastrectomy (SG) significantly improves nonalcoholic fatty liver disease (NAFLD) at 1 year postsurgery.
Why this matters
- Few data exist regarding the effect of this popular bariatric procedure on NAFLD evolution.
- Authors comment: “SG could avoid a liver transplant in obese patients with NAFLD, and thus NAFLD should be included as a formal indication for bariatric surgery.”
- Argentinian study of 63 obese patients (mean age, 40±10 years; 65% female) undergoing laparoscopic SG with intraoperative liver biopsy.
- Repeat biopsy was performed in 43 patients after 1 year; the remaining 20 underwent laboratory testing only.
- Funding: None disclosed.
- At baseline, 90.5% of patients had steatosis (G1, 54%; G2, 27%; G3, 9.5%), and 50.8% had some degree of steatohepatitis (G1, 42.9%; G2, 4.8%; G3, 3.1%).
- 39.7% had steatosis + steatohepatitis.
- At 1 year post-SG:
- Mean weight loss, 32%±6% (P<.0001>
- Lipid panels: improved high-density lipoprotein cholesterol (P=.027) and triglycerides (P=.001).
- Liver function tests improved (all P<.0001>
- Glycemia, HbA1c, oral glucose tolerance test, insulin level, and homeostatic model assessment of insulin resistance (HOMA-IR) all improved (all P<.0001>
- Monocentric design; small sample size.