- Nonalcoholic fatty liver disease (NAFLD) is independently associated with an increased risk for myocardial infarction (MI).
Why this matters
- Careful monitoring and early management may be necessary, even in mild NAFLD.
- Study of 111,492 patients aged >40 (mean, 52.0±8.1) years undergoing regular health exams over a 10-year period (2003-2013).
- Baseline NAFLD prevalence was 33.4%; most patients had low NAFLD fibrosis score (NFS;
- Patients with history of cardiovascular disease, liver disease, or cancer were excluded.
- NAFLD was diagnosed via ultrasound.
- Funding: None.
- 183 patients experienced an MI over 725,706.9 person-years of follow-up, corresponding to an incidence rate of 2.5 cases per 10,000 person-years.
- NAFLD was tied to a doubled risk for MI (aHR=2.14; P<.01 in multivariate analysis adjusting for age sex and visit year.>
- The association retained significance in fully adjusted models (aHR=1.54; P=.01) accounting for smoking, alcohol intake, metabolic factors, and medication use.
- In the fully adjusted model, MI risk was similar among patients with:
- Low NFS score: aHR=1.70 (95% CI, 1.22-2.36).
- Intermediate-high NFS score: aHR=1.88 (95% CI, 1.24-2.87).
- Retrospective data.
- Absence of biopsy data.
- Korean population.