National Institute for Health and Care Excellence (NICE) has recommended peginterferon beta-1a (Plegridy) as a treatment option for relapsing-remitting multiple sclerosis (MS) for routine use within NHS England.
Peginterferon beta-1a is recommended for the treatment of adults with relapsing-remitting MS, within its marketing authorisation. The drug has been licensed for the same since 2014.
The recommended dose for peginterferon beta-1a is 125 µg administered subcutaneously every two weeks. Clinical trial evidence has shown peginterferon beta-1a to slow disease progression and decrease the frequency of relapses compared with placebo. Indirect comparison of peginterferon beta-1a with other beta interferons and glatiramer acetate has shown comparable effectiveness; however, peginterferon beta-1a needs to be injected less frequently than other beta interferons.
NICE has determined the cost-effectiveness estimates for peginterferon beta-1a to be favourable for use within the NHS.
In May 2018, NICE had conducted a review of several MS drugs and was unable to make a recommendation on peginterferon beta-1a at that time. However, NICE has reversed its earlier decision after a separate appraisal.
"We are pleased that NICE has approved Plegridy for people with relapsing-remitting MS," said David Martin, Chief Executive Officer of Multiple Sclerosis Trust, the leading national charity for the condition that contributed throughout the appraisal process.