- Delayed vs timely esophagectomy was associated with increased perioperative mortality, but not OS, after chemoradiation for clinical stage II/III esophageal adenocarcinoma.
Why this matters
- Delayed and salvage esophagectomy have been found to be associated with worse outcomes in previous studies, but this study showed worse outcomes only in perioperative survival.
- Retrospective analysis of 8489 records from the National Cancer Database.
- Funding: None disclosed.
- 92.1% of patients underwent timely esophagectomy (
- Median post-CRT surgical delay was 49 days in the timely esophagectomy group and 109 days in the delayed group.
- The delayed group was more likely to be black (2.3% vs 1.2%; P=.007) and to be on Medicare (47.9% vs 39.8%; P<.001 chemotherapy regimens radiation dose and surgical approach were similar between the groups.>
- Pathological complete response was more frequent in the delayed group (22.2% vs 18.6%; P=.043).
- 90-day postoperative mortality was higher in the delayed group (10.4% vs 7.8%; P<.005 but there was no difference in os with either a delay or>120 days delay.
- Retrospective analysis.