NSCLC: delayed adjuvant chemotherapy still yields benefit

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  • Patients with NSCLC may continue to benefit from adjuvant chemotherapy even when it is administered beyond the traditional postoperative window.
Why this matters
  • In appropriate patients, physicians should consider chemotherapy up to 4 mo after surgery if patients are able to tolerate it.
Study design
  • Retrospective observational study that evaluated 12, 473 treatment-naive patients with NSCLC identified from the National Cancer Database with completely resected tumors and who received adjuvant multiagent chemotherapy between 18 and 127 d after surgery.
  • Funding: Not disclosed.
Key results
  • 3 groups were identified: earlier subgroup (18-38 d in chemotherapy initiation), reference interval (39-56 d), and later subgroup (57-127 d).
  • There was no consistent correlation between mortality risk and timing of adjuvant chemotherapy:...