NSCLC follow-up: does timing of CT surveillance matter?

  • Clin Lung Cancer

  • curated by Kelli Whitlock Burton
  • Univadis Clinical Summaries
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Takeaway

  • Beginning CT surveillance earlier after surgery for stage IA NSCLC offers no survival advantage over beginning surveillance later.

Why this matters

  • Current guidelines for surveillance after curative NSCLC therapy are inconsistent about the ideal timing and technique.

Study design

  • 294 patients with stage IA NSCLC underwent R0 resection with no induction or adjuvant therapy.
  • Subgroup analysis of 187 patients who underwent CT surveillance at 6±3 months (early CT; n=94) or 12±3 months (late CT; n=93).
  • Funding: None.

Key results

  • In the overall cohort, 49 patients had recurrence and 45 had new NSCLC diagnoses.
  • In the subgroup, 21 patients had recurrence and 31 had new NSCLC diagnoses.
  • More patients with new NSCLC underwent CT surveillance vs those with recurrence (87% vs 57%; P=.003).
  • The late CT group had significantly longer follow-up than the early CT group (56 vs 36 months; P<.01 but the early ct group had more scans vs p=".04).</li">
  • No significant difference was seen between groups in incidence of new or recurrent disease, unadjusted 5-year OS, or disease treatment among those with recurrence.

Limitations

  • Retrospective, single-center study.