- In patients with obstructive sleep apnoea (OSA), periodic limb movements during sleep (PLMS), at least with a frequency of ≥25 events per hour, is associated with an increased systolic blood pressure (SBP).
Why this matters
- Findings concerning the outcomes of the association between PLMS and OSA have shown inconsistent results regarding the sleepiness or cardiovascular complications.
- Cross-sectional study included 1487 patients with OSA recruited in the European Sleep Apnoea Database (ESADA) study.
- All patients were divided into 2 groups:
- patients with significant PLMS (frequency of ≥25 events per hour; group 1; n=132) and
- patients without significant PLMS Index (PLMSI frequency of
- Funding: European Union COST Action B26 and others.
- In the univariate analysis, SBP was significantly higher in patients with OSA and significant PLMS vs those without significant PLMSI (135.7, mean standard deviation [SD]17.70] mmHg vs 130.90, SD 14.64] mmHg: P<.001>
- After adjustment for confounders, increase in SBP (+2.64 mmHg; P=.044) remained significant in patients with OSA and significant PLMS vs those without significant PLMSI.
- No significant increment was observed in diastolic BP (0.99 mmHg; P=.310) and pulse pressure (1.64 mmHg; P=.119) between patients with OSA and significant PLMS vs those without significant PLMSI.
- Study did not evaluate causal link between PLMS and BP elevation.
- Risk of bias.