Optimal timing of antenatal corticosteroids with preterm delivery

  • Am J Obstet Gynecol MFM

  • International Clinical Digest
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Takeaway

  • Antenatal corticosteroids administered 2-7 days prior to delivery have the greatest effect in preventing neonatal respiratory distress syndrome.

Why this matters

  • Premature birth is responsible for a large proportion of neonatal morbidity and mortality worldwide.

Key results

  • 56.4% study neonates were diagnosed with respiratory distress syndrome and 27.3% with major neonatal morbidity.
  • Neonates exposed to antenatal corticosteroids for 2 to
  • 2 to
  • 7 to
  • ≥14 days: 2.34 (P<.001>

Study design

  • Secondary analysis of 2 multicenter studies of the effects of antenatal magnesium sulfate.
  • Women with singleton pregnancies who received a single dose of antenatal corticosteroids and delivered between 23 weeks 0 days and 33 weeks 6 days were included (n=2259).
  • Primary outcome was respiratory distress syndrome in the neonate.
  • Funding: Eunice Kennedy Shriver National Institute of Child Health and Human Development Genomic and Proteomic Network for Preterm Birth Research.

Limitations

  • Studies were conducted over different time periods and had different protocols.