- Obstructive sleep apnea (OSA) was found in more than three-quarters of a high-risk population enrolled in a lung cancer screening program.
- Patients with significant nocturnal hypoxemia were more than twice as likely to have a positive lung cancer screening.
Why this matters
- There were no studies on sleep-disordered breathing in patients undergoing lung cancer screening, although animal studies had shown an association between nocturnal hypoxemia and lung cancer.
- 236 patients in the SAILS prospective trial underwent low-dose CT lung cancer screening and home sleep apnea testing.
- Nocturnal hypoxemia defined as the percentage of sleep time spent with an oxyhemoglobin saturation
- Funding: None disclosed.
- Lung cancer prevalence at baseline was 1.3%.
- 62.1% had COPD and 74.2% had emphysema.
- 77.5% had OSA (36.4% mild, 23.3% moderate, 17.8% severe).
- Mean T90 was 4.60 and mean apnea-hypopnea index (AHI) was 16.60.
- After multivariable analysis, snoring was associated with AHI stratified by OSA (aOR, 5.78; P=.001).
- Patients with significant nocturnal hypoxemia (T90 >12%) were more likely to have a positive lung cancer screening, after adjusting for possible confounders (aOR, 2.6; P=.027).
- Single-center study with no control group.